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. 2016 Oct 12;1(6):472–493. doi: 10.1016/j.jacbts.2016.06.008

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Transcriptional Signature Activated During CPC Differentiation Into Cardiomyocytes

(A) Principal component analysis of genes differentially expressed during differentiation of CPCs into either cardiomyocytes or smooth muscle cells. Groups are indicated in the figure. Numbers refer to Supplemental Table 2. (B) Hierarchical clustering of genes differentially expressed during differentiation of CPCs into either cardiomyocytes or smooth muscle cells. Groups are indicated in the Figure. Gene ontology (Go) terms and biological processes annotated by Gene Go are indicated. (C) Venn diagram of up- and down-regulated genes common or unique to fetal CPCs differentiating in cardiomyocytes (blue), adult CPCs differentiating into smooth muscle cells (green), and adult CPCs differentiating into cardiomyocytes following exposure to DLL1 and DAPT treatment (red). Gene ontology terms and biological processes annotated by Gene Go are indicated for sets of genes common to cells differentiating into cardiomyocytes, and for set of genes unique to cells differentiating into smooth muscle cells. Abbreviations as in Figure 1.

Transcriptional Signature Activated During CPC Differentiation Into Cardiomyocytes

(A) Principal component analysis of genes differentially expressed during differentiation of CPCs into either cardiomyocytes or smooth muscle cells. Groups are indicated in the figure. Numbers refer to Supplemental Table 2. (B) Hierarchical clustering of genes differentially expressed during differentiation of CPCs into either cardiomyocytes or smooth muscle cells. Groups are indicated in the Figure. Gene ontology (Go) terms and biological processes annotated by Gene Go are indicated. (C) Venn diagram of up- and down-regulated genes common or unique to fetal CPCs differentiating in cardiomyocytes (blue), adult CPCs differentiating into smooth muscle cells (green), and adult CPCs differentiating into cardiomyocytes following exposure to DLL1 and DAPT treatment (red). Gene ontology terms and biological processes annotated by Gene Go are indicated for sets of genes common to cells differentiating into cardiomyocytes, and for set of genes unique to cells differentiating into smooth muscle cells. Abbreviations as in Figure 1.