Table 3.
Representation of the private epimutations (lines) in each converter (columns, n = 14)
| Genes | CpG | IC01.001 | IC01.010 | IC01.037 | IC01.048 | IC01.055 | IC01.063 | IC01.098 | IC01.105 | IC01.119 | IC01.151 | IC01.153 | IC01.178 | IC05.001 | IC25.001 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Before transition | |||||||||||||||
| ALG11; ATP7B | cg18796523 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CACNB4 | cg04087237 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 |
| — | ch.16,50203861R | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | −0.01 | −0.01 |
| NT5DC3 | cg13303475 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | −0.01 | 0.00 |
| UBE2T | cg01918706 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | −0.01 | 0.01 |
| KLHL22 | cg01657694 | 0.00 | 0.01 | 0.00 | 0.00 | −0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | −0.01 | 0.00 |
| SIM2 | cg13694867 | 0.00 | −0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 |
| EFEMP1 | cg05168033 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | −0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | −0.01 | 0.00 |
| ADCY9 | cg26952925 | 0.00 | −0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | −0.01 | 0.00 | 0.00 | 0.01 |
| GPR27; EIF4E3 | cg13562542 | 0.01 | 0.00 | 0.00 | 0.00 | −0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| PELI1 | cg17364044 | −0.01 | 0.01 | −0.01 | 0.00 | 0.01 | 0.00 | −0.01 | 0.00 | 0.00 | 0.01 | −0.01 | 0.00 | 0.00 | 0.00 |
| GAS1 | cg26447413 | 0.00 | −0.01 | −0.01 | 0.01 | 0.00 | 0.00 | −0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 |
| TMEM132C | cg11265160 | 0.00 | −0.01 | −0.01 | 0.01 | −0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | −0.01 |
| LIME1 | cg21849932 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.00 | −0.01 | 0.01 | 0.00 | 0.00 | −0.01 | 0.01 |
| FAM160B1 | cg04364540 | −0.01 | 0.00 | 0.01 | 0.00 | 0.02 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | −0.01 | −0.01 | −0.01 |
| PLCXD3 | cg14099514 | 0.00 | 0.00 | −0.01 | 0.00 | −0.01 | 0.00 | −0.01 | −0.02 | 0.00 | 0.00 | −0.02 | 0.02 | 0.00 | 0.01 |
| — | cg19176559 | −0.01 | −0.01 | 0.01 | 0.00 | −0.02 | 0.01 | −0.01 | −0.01 | 0.01 | 0.01 | 0.01 | −0.01 | 0.00 | 0.01 |
| SPHK1 | cg19041132 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| — | cg12053442 | −0.01 | 0.00 | −0.01 | 0.02 | 0.01 | 0.01 | −0.03 | 0.00 | −0.01 | 0.02 | −0.01 | 0.00 | 0.01 | −0.01 |
| HBM | cg01558909 | 0.00 | −0.01 | −0.01 | 0.00 | 0.01 | 0.01 | −0.01 | 0.03 | 0.01 | 0.02 | −0.01 | 0.01 | 0.00 | −0.01 |
| PCSK9 | cg14993491 | −0.02 | 0.01 | 0.02 | −0.02 | 0.01 | 0.02 | −0.03 | −0.01 | 0.05 | 0.03 | −0.04 | −0.02 | 0.02 | −0.02 |
| — | cg13408519 | 0.02 | 0.00 | −0.01 | 0.02 | 0.00 | 0.02 | 0.00 | −0.02 | −0.01 | 0.02 | 0.01 | 0.00 | −0.01 | −0.01 |
| CTSH | cg12604181 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | −0.01 |
| RAC1 | cg18404925 | 0.00 | 0.00 | −0.01 | −0.01 | 0.01 | 0.01 | −0.02 | 0.00 | 0.01 | −0.03 | 0.01 | 0.00 | −0.01 | −0.03 |
| ASTN2 | cg13978347 | −0.01 | −0.03 | 0.00 | 0.06 | −0.02 | 0.02 | 0.01 | 0.00 | 0.03 | 0.01 | 0.06 | −0.04 | 0.00 | 0.00 |
| After transition | |||||||||||||||
| Antipsychotic introduction | × | × | × | × | × | × | |||||||||
| ALG11; ATP7B | cg18796523 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | −0.01 | 0.03 | 0.01 | 0.00 | 0.00 | 0.00 |
| CACNB4 | cg04087237 | 0.04 | 0.02 | 0.00 | −0.01 | 0.00 | 0.00 | −0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | −0.01 |
| — | ch.16.50203861R | 0.00 | −0.01 | 0.00 | −0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.01 | 0.00 | 0.00 |
| NT5DC3 | cg13303475 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | −0.01 | −0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.06 | −0.01 | 0.00 |
| UBE2T | cg01918706 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | −0.01 |
| KLHL22 | cg01657694 | 0.03 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.06 | 0.00 | 0.00 | 0.00 | 0.01 | −0.01 | −0.01 |
| SIM2 | cg13694867 | 0.02 | 0.00 | −0.01 | 0.01 | −0.01 | −0.02 | 0.00 | 0.00 | −0.03 | −0.01 | 0.00 | −0.01 | 0.00 | 0.05 |
| EFEMP1 | cg05168033 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | −0.01 | −0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.06 |
| ADCY9 | cg26952925 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | −0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | −0.01 | 0.00 | 0.08 |
| GPR27; EIF4E3 | cg13562542 | 0.07 | 0.00 | −0.02 | 0.01 | 0.00 | 0.00 | −0.01 | −0.01 | 0.01 | 0.00 | 0.00 | 0.01 | −0.01 | 0.01 |
| PELI1 | cg17364044 | 0.00 | −0.02 | −0.01 | −0.01 | −0.02 | 0.00 | 0.00 | 0.10 | 0.00 | 0.01 | 0.01 | −0.01 | −0.01 | 0.00 |
| GAS1 | cg26447413 | −0.01 | 0.01 | 0.00 | 0.01 | −0.02 | −0.01 | −0.01 | −0.02 | 0.01 | 0.10 | −0.01 | 0.00 | 0.02 | 0.00 |
| TMEM132C | cg11265160 | 0.01 | 0.08 | 0.00 | 0.01 | −0.02 | −0.05 | −0.04 | −0.01 | 0.00 | 0.00 | −0.06 | 0.00 | 0.01 | 0.00 |
| LIME1 | cg21849932 | −0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.01 | 0.13 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | −0.01 | 0.00 |
| FAM160B1 | cg04364540 | 0.00 | −0.01 | −0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | −0.01 | 0.00 | 0.00 | 0.15 | −0.02 | 0.00 |
| PLCXD3 | cg14099514 | 0.02 | 0.03 | −0.01 | 0.00 | −0.02 | −0.04 | −0.01 | 0.00 | −0.01 | 0.14 | −0.03 | 0.02 | 0.00 | 0.00 |
| — | cg19176559 | 0.04 | −0.03 | 0.00 | 0.00 | −0.01 | −0.02 | 0.15 | 0.01 | 0.00 | 0.01 | −0.02 | 0.01 | 0.00 | 0.02 |
| SPHK1 | cg19041132 | 0.00 | 0.00 | 0.00 | 0.02 | 0.12 | −0.01 | 0.00 | 0.01 | 0.00 | 0.00 | −0.01 | 0.13 | −0.01 | 0.00 |
| — | cg12053442 | −0.01 | −0.01 | 0.01 | −0.01 | 0.00 | 0.00 | −0.01 | −0.15 | 0.01 | 0.00 | 0.02 | 0.00 | 0.01 | −0.11 |
| HBM | cg01558909 | 0.20 | 0.00 | −0.01 | −0.01 | 0.01 | 0.29 | 0.07 | 0.00 | −0.02 | 0.03 | 0.01 | 0.00 | −0.01 | 0.00 |
| PCSK9 | cg14993491 | −0.04 | 0.25 | 0.02 | −0.05 | −0.04 | 0.36 | −0.05 | −0.02 | −0.01 | 0.02 | −0.01 | 0.01 | 0.01 | 0.02 |
| — | cg13408519 | −0.01 | 0.01 | −0.01 | 0.01 | −0.02 | −0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.01 | −0.01 | 0.46 |
| CTSH | cg12604181 | 0.00 | 0.00 | 0.00 | 0.54 | 0.09 | 0.01 | 0.01 | 0.00 | −0.01 | 0.00 | 0.01 | −0.01 | −0.02 | 0.00 |
| RAC1 | cg18404925 | −0.03 | −0.01 | 0.00 | 0.06 | 0.63 | 0.03 | −0.01 | −0.01 | 0.00 | 0.03 | 0.02 | 0.01 | −0.02 | −0.02 |
| ASTN2 | cg13978347 | 0.04 | −0.02 | 0.02 | −0.01 | 0.01 | 0.01 | 0.03 | 0.02 | −0.05 | −0.04 | 0.02 | −0.71 | −0.03 | −0.01 |
The value in each case correspond to the deviation from the individual β-value to the group median: relative hypermethylation is in bold and relative hypomethylation in italics