Table 1.
Demographic, blood gas values and mean arterial blood pressure variables in patients with a pulmonary (PH) and/or cerebral intraventricular (IVH) haemorrhage and healthy controls (results are expressed as number (%), median and (IQR)).
| Variable | PH-IVH patients (NH = 8) | Healthy controls (NC = 11) | p-value** |
|---|---|---|---|
| Male gender [%] | 4/8 (50) | 5/11 (46) | 0.85 |
| Antenatal steroids [%] | 2/8 (25) | 6/11 (55) | 0.20 |
| Birth weight [g] | 710 (655, 780) | 910 (600, 1020) | 0.14 |
| Gestational age [wk] | 24.8 (24.3, 25.3) | 25.7 (24.9, 27.4) | 0.15 |
| Length of stay [days] | 115 (110, 148) | 97 (77, 119) | 0.26 |
| APGAR | |||
| at 5 min | 6 (4, 8) | 6 (5, 9) | 0.22 |
| at 10 min | 8 (6, 9) | 7 (6, 9) | 0.85 |
| Respiratory distress syndrome [%] | 8/8 (100) | 11/11 (100) | — |
| Ventilation parameters at H6 [%] | |||
| CMV and HFOV | 8/8 (100) | 6/11 (55) | 0.03 |
| NIV or CPAP | 0/8 (0) | 5/11 (46) | 0.03 |
| Ventilation parameters at H24 [%] | |||
| CMV and HFOV | 7/8 (88) | 6/11 (55) | 0.13 |
| NIV or CPAP | 1/8 (13) | 5/11 (46) | 0.13 |
| Ventilation parameters at H48 [%] | |||
| CMV and HFOV | 7/8 (88) | 8/11 (73) | 0.44 |
| NIV or CPAP | 1/8 (13) | 3/11 (27) | 0.44 |
| Ventilation parameters at H72 [%] | |||
| CMV and HFOV | 7/8 (88) | 4/11 (36) | 0.03 |
| NIV or CPAP | 1/8 (13) | 6/11 (55) | 0.06 |
| Blood gas analysis* | |||
| pH | 7.24 (7.21, 7.28) | 7.28 (7.24, 7.30) | 0.15 |
| PaCO2 [mmHg] | 48.03 (46.35, 51.53) | 47.46 (42.83, 50.74) | 0.61 |
| HGB [g/dl] | 120.88 (116.10, 123.73) | 137.00 (123.38, 142.71) | 0.03 |
| Lactates | 2.69 (2.17, 3.74) | 2.16 (1.80 2.72) | 0.10 |
| Mean arterial blood pressure* | |||
| MABP [mmHg] | 30.47 (28.87, 31.67) | 34.36 (32.79, 36.21) | 0.02 |
Interquartile range (IQR); conventional mechanical ventilation (CMV); high frequency oscillation ventilation (HFOV); non-invasive ventilation (NIV); Continuous positive airway pressure (CPAP); haemoglobin concentration in the blood (HGB); partial pressure of carbon dioxide (PaCO2); mean arterial blood pressure (MABP). *Median values of blood gas analyses and MABP measurements averaged over the 72 h of life. **p-values are generated with statistical comparisons of the means using general linear mixed models adjusted with Bonferroni correction.