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. 2018 Apr 25;9(5):488. doi: 10.1038/s41419-018-0537-6

Fig. 7. IDH2 deficiency exacerbates apoptosis after cisplatin administration.

Fig. 7

Idh2‒/‒ mice and wild-type (Idh2+/+) littermates were intraperitoneally injected with either cisplatin (C, 20 mg/kg B.W.) or 0.9% saline (vehicle, V) once. Some mice were treated with Mito-T (M, 0.7 mg/kg B.W.) daily, beginning 7 days before cisplatin injection and continuing until experiments were completed. Kidneys were harvested 3 days after cisplatin injection. Kidney sections were stained using a TUNEL assay kit. a Immunostaining shows TUNEL-positive cells (green). Nuclei were stained with DAPI (blue). b TUNEL-positive cells were counted in 10 fields per kidney. Results are expressed as means ± SE (n = 3 per group). Scale bars: a 50 µm. *p < 0.05 vs. respective V; #p < 0.05 vs. respective C; †p < 0.05 vs. C in Idh2+/+