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. 2018 Apr 26;9(5):463. doi: 10.1038/s41419-018-0558-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — GILZ, through interactions with different transcription factors (as explained in the text), affects the cells of the immune system, thus mediating the physiological and pharmacological effects of GCs. The final outcome of GILZ expression is immunosuppression, which is the desired effect when GCs are administered for therapeutic purposes, but strongly affects tumor growth with an effect that involves both systemic and tumor microenvironment immune cells