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. 2018 Apr 25;8:6509. doi: 10.1038/s41598-018-24270-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Difference in mean (Δ = log2H/L_PCa − log2H/L_BPH) plotted by M-LAC fraction per protein. Asterisk denotes a statistically significant difference in mean (p ≤ 0.05). Proteins are grouped by expression patterns: (A) Quantitated in all fractions and significantly different in all fractions; (B) Significantly different in every M-LAC fraction it was quantitated in; (C) Only significant at the global protein level; (D) Significantly different in multiple M-LAC fractions; (E) Significantly different in only one M-LAC fraction and at the global protein level; (F) Significantly different in one M-LAC fraction and not at the global protein level.