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. 2018 Apr 26;8:92. doi: 10.1038/s41398-018-0141-7

Fig. 2. Comparative effects of PF-3845, JZL184 and JZL195 on foot shock-induced anxiety-like behavior in the elevated zero maze or light–dark box.

Fig. 2

a Schematic diagram depicts the timeline of the experiment. The effects of PF-3845 (1 mg kg–1), JZL184 (10 mg kg–1) and JZL195 (10 mg kg–1) systemic administration on the b open arm entries, c time immobile in open arm, d open arm exit latency, e total time immobile, f total distance and g % open arm time in the EZM. The effects of PF-3845 (1 mg kg–1), JZL184 (10 mg kg–1) and JZL195 (10 mg kg–1) systemic administration on the h percent light time, i percent light distance and j total distance traveled in 10 min in the light–dark box assay. Significant F and P-values from one-way analysis of variance noted above bar graphs; *P < 0.05, **P < 0.01, vs. stress group by Holm–Sidak post hoc multiple comparisons test in bar graphs. Data are presented as means ± SEM. EZM elevated zero maze, LD light–dark box, FS foot shock