Table 3.
Effects of L. reuteri on early-life diseases.
| Target | Strain | Duration | Subjects | Result | Citation |
|---|---|---|---|---|---|
| Early caries lesions | DSM 17938, ATCC PTA 5289 | 3 months | Adolescent | No significant change in fluorescence or lesion area | Keller et al., 2014 |
| Caries | ATCC 55730 | First year life | Infants | Reduced prevalence of caries and gingivitis score when the kids were 9 years old | Stensson et al., 2014 |
| FAP | DSM 17938 | 4 weeks | FAP children | Significant decrease in the frequency and intensity of functional abdominal pain | Weizman et al., 2016 |
| FAP | DSM 17938 | 4 weeks | FAP children | Significant reduction of pain intensity | Romano et al., 2014 |
| Infectious diarrhea | DSM 17938 | 5 days | Children | Safe and well-tolerated; decreased duration of diarrhea | Dinleyici et al., 2015 |
| Rotavirus diarrhea | - | Up to 5 days | Young children | Shortened diarrhea duration and large decrease in the occurrence of watery diarrhea | Shornikova et al., 1997a,b |
| Nosocomial diarrhea | DSM 17938 | During hospital stay | Children | No effect on the overall incidence of diarrhea, including that related to rotavirus infection | Wanke and Szajewska, 2012 |
| Acute diarrhea | DSM 12246 (with 19070-2) | 5 days | Children patients | Decreased duration of diarrhea; decreased period of rotavirus excretion | Rosenfeldt et al., 2002a,b |
| Acute diarrhea | DSM 17938 | 3 days | Children | Decrease in diarrhea frequency, duration, and relapse | Francavilla et al., 2012 |
| Acute diarrhea | DSM 17938 | 5 days | Hospitalized children | Effective decrease of the duration of acute diarrhea | Dinleyici et al., 2014 |
| Diarrhea | ATCC 55730 | 12 weeks | Infants | Fewer and shorter diarrhea episodes | Weizman et al., 2005 |
| Diarrhea | DSM 17938 | 6 months | Children | Reduced incidence of diarrhea | Agustina et al., 2012 |
| Diarrhea | DSM 17938 | 3 months | Children | Decrease in diarrhea episodes and duration; Benefits against respiratory infection | Gutierrez-Castrellon et al., 2014 |
| Infant colic | DSM 17938 | 3 weeks | Breastfed infants | Significant reduction in crying time | Mi et al., 2015 |
| Infant colic | DSM 17938 | 3 weeks | Breastfed infants | Reduction in crying and fussing time | Chau et al., 2015 |
| Infant colic | DSM 17938 | 12 weeks | Newborns | Effective preventive and protective action | Savino et al., 2015a |
| Infant colic | ATCC 55730 | 28 days | Breastfed infants | Significantly improvement of colicky symptoms compared with simethicone | Savino et al., 2007 |
| Infant colic | DSM 17938 | 21 days | Breastfed infants | Improved symptoms; Increase of Lactobacilli increase and decrease of E. coli in the fecal microbiota | Savino et al., 2010 |
| Infant colic | DSM 17938 | 21 days | Colicky infants | No effect on the global microbiota composition | Roos et al., 2013 |
| Infant colic | DSM 17938 | 21 days | Breastfed infants | Higher rate of responders and reduced median crying time | Szajewska et al., 2013 |
| Infant colic | DSM 17938 | 1 month | Infants | No effect on crying time | Sung et al., 2014 |
| Infant colic | DSM 17938 | 90 days | Infants | Significant reduction of the mean crying time | Indrio et al., 2014 |
| Infant growth | DSM 17938 | 98 days | Healthy infants | Well-tolerated but no improvement on growth | Cekola et al., 2015 |
| Atopic dermatitis | DSM 122460 (with 19070-2) | 6 weeks | AD children | Improvement of eczema; more pronounced in allergic patients | Rosenfeldt et al., 2003, 2004 |
| Atopic dermatitis | ATCC 55730 | 8 weeks | AD children | Positive modulation of cytokine pattern in the exhaled breath condensate | Miniello et al., 2010 |
| Eczema | ATCC 55730 | -1 to 12 month old | Infants with family Allergic history | No protection of the general occurrence of eczema; Prevention of IgE-associated eczema | Abrahamsson et al., 2007 |
| GI motility | - | 30 days | Newborns | Faster gastric emptying | Indrio et al., 2009 |
| Respiratory allergy | ATCC 55730 | -1 to 12 month old | Infants | No effect on the prevalence of asthma, eczema or other allergic diseases later in life | Abrahamsson et al., 2013 |
| Feeding intolerance | DSM 17938 | Until out of NICU | Preterm infants | Decrease in feeding intolerance and duration of hospitalization | Rojas et al., 2012 |
| Necrotising enterocolitis | DSM 17938 | Until discharge | Preterm infants | No effect on NEC rate; Decrease in feeding intolerance and duration of hospital stay | Oncel et al., 2014 |
| Regurgitation | DSM 17938 | 28 days | Infants | Prevention of regurgitation during the first month of life | Garofoli et al., 2014 |
| Regurgitation | DSM 17938 | 90 days | Infants | Significant reduction of the mean number of regurgitation | Indrio et al., 2014 |
FAP, functional abdominal pain; NICU, neonatal intensive care unit; NEC, necrotising enterocolitis.