Table 1.
Parameters of the AB model.
| S | References + biological meaning | Value |
|---|---|---|
| km12 | [est] Transition rate M1-M2 | 0.075 day−1 |
| k2 | (Porcheray et al., 2005) Activation rate of IL1 for M1 | 0.1 ml/pg/day |
| k3 | (Porcheray et al., 2005) Activation rate of TNFα for M1 | 1 ml/pg/day |
| k4 | (Porcheray et al., 2005) Activation rate of IL10 for M2 | 0.3 ml/pg/day |
| k5 | (Edwards et al., 2006) Secretion rate of IL10 by M2 | 5e−4 pg/cell/day |
| k6 | (Wang et al., 2012) Secretion rate of TNFa by M1 | 7e−4 pg/cell/day |
| k7 | (Meng and Lowell, 1997; Mantovani et al., 2004) Secretion rate of IL1 by M1 | 5e−4 pg/cell/day |
| k8 | (Huang et al., 2002) Secretion rate of TGFβ by M2 | 0.07 pg/cell/day |
| k9 | (Cobbold and Sherratt, 2000) Secretion rate of TGFβ by F | 0.04 pg/cell/day |
| k10 | (Hehenberger et al., 1998) Fibroblast growth rate | 0.924 cell/day |
| k11 | (Ignotz and Massagué, 1986) Collagen deposition rate by F | 20 μg/cell/day |
| k12 | [est] Secretion rate of MP9 by M1 | 3 pg/cell/day |
| k13 | [est] Secretion rate of IL8 by M2 | 5e−4 pg/cell/day |
| k14 | [est] Recruit. of neutrophils by IL8 | 8 pg/ml |
| k15 | [est] Secretion rate of elastase by N | 3 pg/cell/day |
| km21 | (Steinmüller et al., 2000) Transition rate M2-M1 | 0.05 day−1 |
| μ | (Bellingan et al., 1996) Macrophage emigration rate | 0.2 day−1 |
| μN | [est] Neutrophils emigration rate | day−1 |
| cIL1 | (Onozaki et al., 1988) IL1 promotion on M1 | 10 pg/ml |
| cTα | (Onozaki et al., 1988) TNFa promotion on M1 | 10 pg/ml |
| cIL10 | (Onozaki et al., 1988) IL10 promotion on M2 | 5 pg/ml |
| c1 | (Wang et al., 2012) IL10 inhibition on IL10 | 100 pg/ml |
| c | (Marino et al., 2008) IL10 inhibition on IL1 TNFα | 25 pg/ml |
| dIL10 | (Jin and Lindsey, 2010) Decay rate of IL10 | 2.5 day−1 |
| dTa | (Oliver et al., 1993; Tsutsumi et al., 1996) Decay rate of TNFa | 55 day−1 |
| dIL1 | (Lenga et al., 2008) Decay rate of IL1 | 0.2 day−1 |
| dTb | (Zhang et al., 2003) TGFβ degradation rate | 15 day−1 |
| dFC | (Darby et al., 1997) Fibroblast apoptosis rate | 0.12 day−1 |
| dM | (Eberhardt et al., 2002; Moro et al., 2008) MMP degradation rate | 0.875 day−1 |
| λ | (Horio et al., 1998; Maass et al., 2002) Sec. rate TGFβ by Mc | 5e−6 pg/c/d |