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. 2018 Apr 25;8:6508. doi: 10.1038/s41598-018-23862-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between normoglycemia time and islet parameters of animals for which pre-implant data is available. Time period during which normoglycemia was maintained: (1) none, (2) >0–4 wk, (3) 4–8 wk, and (4) 8 wk or explantation while still normoglycemic. (A) Datum point for each animal plotted at its corresponding OCR and number of IEQ. Data field is segregated into nine regions defined by IEQ ≤ 2050, 2050 ≤ IEQ ≤ 2425, and 2425 ≤ IEQ; OCR ≤ 5850, 5850 ≤ OCR ≤ 7350, and 7350 ≤ OCR. (B) Fraction of normoglycemia times <4 wk (top two symbols) and >4 wk (bottom two symbols) indicated within each region. Average for each row and column is also tabulated in bold. (C) Same data as in (A) plotted on coordinates of IEQ/kg and OCR/DNA. DNA content was calculated using 1,560 cells/IEQ¹³ and 6.5 mg DNA/cell¹⁷. Solid curve was fitted to data for naked transplantation of rat islets into mice¹⁸, given by log₁₀ y = ax + b, where y = IEQ/kg, x = OCR/DNA in nmol/min mg DNA, a = 0.00515 DNA/OCR, and b = 5.45. Dashed lines to left and right of fitted curve are 68% confidence limits associated with fitted curve. (D) Same as (C), with the fraction of normoglycemia time <4 wk (top) and >4 wk (bottom) indicated for each region.