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. 2018 Apr 25;6(8):e13689. doi: 10.14814/phy2.13689

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© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A) Cardiotoxin‐injected (injured) tibialis anterior (TA) muscle mass relative to sham (saline‐injected) muscle mass. Injured muscles were significantly lighter at 7 days postinjury (DPI) in both wild‐type (WT) and CXCL10 knockout (KO) mice. (B) Regenerating (central nucleated) muscle fiber cross‐sectional area (CSA) was significantly reduced in both genotypes at 7 DPI (*P < 0.05) but was recovered similar to muscle fibers of sham muscles by 14 DPI. (C) Representative H&E images from sham and injured muscles. (D) The number of muscle fibers expressing embryonic myosin heavy chain (eMyHC) was greater at 7 DPI in both genotypes. Bars not sharing the same letter (a or b) are significantly different (P < 0.05). (E) Representative images of eMyHC stain at 7 and 14 DPI in WT animals. Red = dystrophin, Green = eMyHC, Blue = DNA. Arrowheads denote examples of eMyHC‐positive muscle fibers. Data are mean ± SD. n = 4–6 per experimental condition. Scale bar is 100 μm.