Figure 2.

Multimodal imaging in patient 3. A, Color fundus photograph identifying multiple yellow flecks distributed throughout the posterior pole of both eyes, sparing the peripapillary retina. B, A 488-nm autofluorescence image revealing that the flecks are highly autofluorescent. In addition, numerous discrete autofluorescent dots are visible at the fovea, a feature of disease that usually is not observed. C, The flecks are predominantly hyporeflective, viewed using near infra-red light, but some appear to have a highly reflective center. D, OCT image (horizontal line scan through the foveola) demonstrating hyperreflectivity at the base of the outer nuclear layer and mild outer retinal degeneration in the temporal macula.