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. 2018 Apr 19;9:376. doi: 10.3389/fphar.2018.00376

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Copyright © 2018 Kossatz, Silva-Peña, Suárez, de Fonseca, Maldonado and Robledo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of an acute administration of octadecylpropyl sulfamide (SUL3, 3 mg/kg; SUL10, 10 mg/kg), vehicle (VEH) and GW6471 (GW, 1 mg/kg) on the memory deficits induced by HI. (A) Discrimination index (DI) at 7 days post-HI in the novel object recognition test in VEH (n = 9 HI mice; n = 7 sham-operated), SUL3 (n = 7 HI mice; n = 8 sham-operated) and SUL10 (n = 6 HI mice; n = 7 sham-operated) treatments groups. A significant decrease in memory was observed in the HI group treated with VEH with respect to sham-operated mice (p < 0.001). This effect was completely reversed by SUL10 (p < 0.001) and partially by SUL3 (p < 0.05). (B) Discrimination index at 7 days post-HI in the novel object recognition test in VEH/VEH (n = 20 HI mice; n = 14 sham-operated), VEH/SUL10 (n = 16 HI mice; n = 13 sham-operated), GW/VEH (n = 12 HI mice; n = 12 sham-operated), and GW/SUL10 (n = 11 HI mice; n = 13 sham-operated) treatments groups. Significant memory deficits were observed in HI mice treated with VEH/VEH with respect to sham-operated mice (p < 0.001). This effect was reversed in the group treated with VEH/SUL10 (p < 0.001), and GW/VEH significantly blocked the beneficial effects of SUL10 (p < 0.001). The administration of GW/VEH did not significantly modify the DI in sham-operated or HI mice with respect to VEH/VEH treatment. Data are expressed as mean + SEM. p < 0.05, p < 0.001 vs. sham-operated mice of the same group; p < 0.05, p < 0.001 vs. VEH/VEH HI mice; ^###p < 0.001 vs. VEH/SUL10 HI mice.

Inline graphic — Effects of an acute administration of octadecylpropyl sulfamide (SUL3, 3 mg/kg; SUL10, 10 mg/kg), vehicle (VEH) and GW6471 (GW, 1 mg/kg) on the memory deficits induced by HI. (A) Discrimination index (DI) at 7 days post-HI in the novel object recognition test in VEH (n = 9 HI mice; n = 7 sham-operated), SUL3 (n = 7 HI mice; n = 8 sham-operated) and SUL10 (n = 6 HI mice; n = 7 sham-operated) treatments groups. A significant decrease in memory was observed in the HI group treated with VEH with respect to sham-operated mice (p < 0.001). This effect was completely reversed by SUL10 (p < 0.001) and partially by SUL3 (p < 0.05). (B) Discrimination index at 7 days post-HI in the novel object recognition test in VEH/VEH (n = 20 HI mice; n = 14 sham-operated), VEH/SUL10 (n = 16 HI mice; n = 13 sham-operated), GW/VEH (n = 12 HI mice; n = 12 sham-operated), and GW/SUL10 (n = 11 HI mice; n = 13 sham-operated) treatments groups. Significant memory deficits were observed in HI mice treated with VEH/VEH with respect to sham-operated mice (p < 0.001). This effect was reversed in the group treated with VEH/SUL10 (p < 0.001), and GW/VEH significantly blocked the beneficial effects of SUL10 (p < 0.001). The administration of GW/VEH did not significantly modify the DI in sham-operated or HI mice with respect to VEH/VEH treatment. Data are expressed as mean + SEM. p < 0.05, p < 0.001 vs. sham-operated mice of the same group; p < 0.05, p < 0.001 vs. VEH/VEH HI mice; ^###p < 0.001 vs. VEH/SUL10 HI mice.