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. 2018 Apr 19;9:376. doi: 10.3389/fphar.2018.00376

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Copyright © 2018 Kossatz, Silva-Peña, Suárez, de Fonseca, Maldonado and Robledo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of an acute administration of octadecylpropyl sulfamide (SUL10, 10 mg/kg) and GW6471 (GW, 1 mg/kg) on the behavioral deficits induced by HI at 24 h and 7 days in VEH/VEH (n = 21 HI mice; n = 14 sham-operated), VEH/SUL10 (n = 16 HI mice; n = 14 sham-operated), GW/VEH (n = 12 HI mice; n = 12 sham-operated), GW/SUL10 (n = 11 HI mice; n = 14 sham-operated) treatment groups. In the Irwin test (A,B), the rotarod test (C,D), and the open field test (G,H) mostly simple effects and no interactions between factors were observed. In the beam walking test (E,F), interactions were observed only 7 days after HI (F), post hoc analysis revealed significant motor coordination deficits in HI mice treated with VEH/VEH (p < 0.01) and GW/SUL10 with respect to sham-operated animals (p < 0.05). Treatment with VEH/SUL10 significantly decreased the arrival latency in HI mice as compared to VEH/VEH administration (p < 0.01), and GW/VEH reversed this effect (p < 0.05). The administration of GW/VEH did not significantly modify the arrival latency in sham-operated or HI mice with respect to VEH/VEH treatment. All data expressed as mean + SEM. p < 0.001 (lesion effect), p < 0.01, p < 0.001 (antagonist effect). In 2F: p < 0.05, p < 0.01 vs. sham-operated mice of the same group; p < 0.01 vs. VEH/VEH HI mice; ^#p < 0.05 vs. VEH/SUL10 HI mice.

Inline graphic — Effects of an acute administration of octadecylpropyl sulfamide (SUL10, 10 mg/kg) and GW6471 (GW, 1 mg/kg) on the behavioral deficits induced by HI at 24 h and 7 days in VEH/VEH (n = 21 HI mice; n = 14 sham-operated), VEH/SUL10 (n = 16 HI mice; n = 14 sham-operated), GW/VEH (n = 12 HI mice; n = 12 sham-operated), GW/SUL10 (n = 11 HI mice; n = 14 sham-operated) treatment groups. In the Irwin test (A,B), the rotarod test (C,D), and the open field test (G,H) mostly simple effects and no interactions between factors were observed. In the beam walking test (E,F), interactions were observed only 7 days after HI (F), post hoc analysis revealed significant motor coordination deficits in HI mice treated with VEH/VEH (p < 0.01) and GW/SUL10 with respect to sham-operated animals (p < 0.05). Treatment with VEH/SUL10 significantly decreased the arrival latency in HI mice as compared to VEH/VEH administration (p < 0.01), and GW/VEH reversed this effect (p < 0.05). The administration of GW/VEH did not significantly modify the arrival latency in sham-operated or HI mice with respect to VEH/VEH treatment. All data expressed as mean + SEM. p < 0.001 (lesion effect), p < 0.01, p < 0.001 (antagonist effect). In 2F: p < 0.05, p < 0.01 vs. sham-operated mice of the same group; p < 0.01 vs. VEH/VEH HI mice; ^#p < 0.05 vs. VEH/SUL10 HI mice.