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. 2018 Apr 19;9:376. doi: 10.3389/fphar.2018.00376

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Copyright © 2018 Kossatz, Silva-Peña, Suárez, de Fonseca, Maldonado and Robledo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of an acute administration of octadecylpropyl sulfamide (SUL10, 10 mg/kg) and GW6471 (GW, 1 mg/kg) on the number of Iba-1 positive cells induced by HI in the ipsilateral hippocampal areas. (A,C) In the CA1, a significant effect of lesion [F(1,50) = 402.4, p < 0.001], and interactions between antagonist and treatment [F(1,50) = 44.9, p < 0.001], antagonist and lesion [F(1,50) = 7.1, p < 0.01], and between antagonist, treatment and lesion [F(1,50) = 31.1, p < 0.001] were observed. (B,D) In the CA3, significant effects of lesion [F(1,50) = 270.2, p < 0.001], and interactions between antagonist and treatment [F(1,50) = 13.8, p < 0.001], antagonist and lesion [F(1,50) = 15.7, p < 0.001], and between antagonist, treatment and lesion [F(1,50) = 9.1, p < 0.01] were observed. Data represent mean + SEM cells per mm² in VEH/VEH (n = 11 HI mice; n = 7 sham-operated), VEH/SUL10 (n = 9 HI mice; n = 8 sham-operated), GW/VEH (n = 6 HI mice; n = 6 sham-operated), GW/SUL10 (n = 5 HI mice; n = 7 sham-operated) treatment groups. The panels show representative images of Iba-1 expression in CA1 (C) and CA3 (D). Scale bar = 100 μm. p < 0.001 vs. sham-operated mice of the same group; p < 0.001 vs. VEH/VEH HI mice; ^###p < 0.001 vs. VEH/SUL10 HI mice.

Inline graphic — Effects of an acute administration of octadecylpropyl sulfamide (SUL10, 10 mg/kg) and GW6471 (GW, 1 mg/kg) on the number of Iba-1 positive cells induced by HI in the ipsilateral hippocampal areas. (A,C) In the CA1, a significant effect of lesion [F(1,50) = 402.4, p < 0.001], and interactions between antagonist and treatment [F(1,50) = 44.9, p < 0.001], antagonist and lesion [F(1,50) = 7.1, p < 0.01], and between antagonist, treatment and lesion [F(1,50) = 31.1, p < 0.001] were observed. (B,D) In the CA3, significant effects of lesion [F(1,50) = 270.2, p < 0.001], and interactions between antagonist and treatment [F(1,50) = 13.8, p < 0.001], antagonist and lesion [F(1,50) = 15.7, p < 0.001], and between antagonist, treatment and lesion [F(1,50) = 9.1, p < 0.01] were observed. Data represent mean + SEM cells per mm² in VEH/VEH (n = 11 HI mice; n = 7 sham-operated), VEH/SUL10 (n = 9 HI mice; n = 8 sham-operated), GW/VEH (n = 6 HI mice; n = 6 sham-operated), GW/SUL10 (n = 5 HI mice; n = 7 sham-operated) treatment groups. The panels show representative images of Iba-1 expression in CA1 (C) and CA3 (D). Scale bar = 100 μm. p < 0.001 vs. sham-operated mice of the same group; p < 0.001 vs. VEH/VEH HI mice; ^###p < 0.001 vs. VEH/SUL10 HI mice.