Table 4.
Lifetime risk (%) of atrial fibrillation in men and women according to risk factor burden, after adjustment for competing risk of death
| Study sample (index age) and risk category | All | Men | Women | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No of atrial fibrillation cases/total | Lifetime risk (95% CI) | P* | P† | No of atrial fibrillation cases/total | Lifetime risk (95% CI) | P* | P† | No of atrial fibrillation cases/total | Lifetime risk (95% CI) | P* | P† | |||
| 55 years | ||||||||||||||
| Optimal | 18/247 | 23.4 (12.8 to 34.5) | <0.001 | — | 7/55 | 29.8 (9.7 to 49.9) | 0.01 | — | 11/192 | 20.5 (7.3 to 33.7) | 0.006 | — | ||
| Borderline | 163/1415 | 33.4 (27.9 to 38.9) | 0.11 | 94/617 | 39.7 (31.7 to 47.7) | 0.37 | 69/798 | 28.0 (20.6 to 35.4) | 0.33 | |||||
| Elevated | 635/3676 | 38.4 (35.5 to 41.4) | 0.009 | 388/1859 | 43.3 (38.4 to 46.2) | 0.20 | 247/1817 | 34.6 (30.3 to 39.0) | 0.05 | |||||
| 65 years | ||||||||||||||
| Optimal | 9/100 | 18.1 (6.7 to 29.4) | <0.001 | — | 4/21 | 28.8 (3.0 to 54.6) | <0.001 | — | 5/79 | 14.9 (2.2 to 27.6) | <0.001 | — | ||
| Borderline | 136/921 | 26.1 (22.0 to 30.1) | 0.19 | 67/359 | 32.1 (25.3 to 38.9) | 0.81 | 69/562 | 22.1 (17.2 to 27.0) | 0.30 | |||||
| Elevated | 878/3784 | 35.8 (33.8 to 37.9) | 0.003 | 464/1746 | 39.7 (36.6 to 42.7) | 0.41 | 414/2038 | 32.7 (30.0 to 35.4) | 0.007 | |||||
| 75 years | ||||||||||||||
| Optimal | 4/33 | 15.4 (1.3 to 29.5) | <0.001 | — | 1/5 | 25.0 (0.0 to 67.4) | 0.09 | — | 3/28 | 13.8 (0.0 to 28.3) | 0.003 | — | ||
| Borderline | 87/492 | 23.6 (19.1 to 28.2) | 0.28 | 42/191 | 28.3 (20.6 to 36.1) | 0.85 | 45/301 | 20.6 (15.0 to 26.1) | 0.38 | |||||
| Elevated | 685/2674 | 32.2 (30.0 to 34.3) | 0.02 | 315/1095 | 36.4 (33.0 to 39.9) | 0.51 | 370/1579 | 29.3 (26.7 to 32.0) | 0.03 | |||||
*
Overall test comparing subhazard distributions across risk categories by Fine-Gray method. P<0.001 for interaction between sex and risk categories for index ages 55, 65, and 75 years.
†
Test comparing lifetime risk in borderline and elevated risk groups with optimal risk group by z ratio test (that is, difference in lifetime risk between two groups divided by its standard error).