Table 4.
Study sample (index age) and risk category | All | Men | Women | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No of atrial fibrillation cases/total | Lifetime risk (95% CI) | P* | P† | No of atrial fibrillation cases/total | Lifetime risk (95% CI) | P* | P† | No of atrial fibrillation cases/total | Lifetime risk (95% CI) | P* | P† | |||
55 years | ||||||||||||||
Optimal | 18/247 | 23.4 (12.8 to 34.5) | <0.001 | — | 7/55 | 29.8 (9.7 to 49.9) | 0.01 | — | 11/192 | 20.5 (7.3 to 33.7) | 0.006 | — | ||
Borderline | 163/1415 | 33.4 (27.9 to 38.9) | 0.11 | 94/617 | 39.7 (31.7 to 47.7) | 0.37 | 69/798 | 28.0 (20.6 to 35.4) | 0.33 | |||||
Elevated | 635/3676 | 38.4 (35.5 to 41.4) | 0.009 | 388/1859 | 43.3 (38.4 to 46.2) | 0.20 | 247/1817 | 34.6 (30.3 to 39.0) | 0.05 | |||||
65 years | ||||||||||||||
Optimal | 9/100 | 18.1 (6.7 to 29.4) | <0.001 | — | 4/21 | 28.8 (3.0 to 54.6) | <0.001 | — | 5/79 | 14.9 (2.2 to 27.6) | <0.001 | — | ||
Borderline | 136/921 | 26.1 (22.0 to 30.1) | 0.19 | 67/359 | 32.1 (25.3 to 38.9) | 0.81 | 69/562 | 22.1 (17.2 to 27.0) | 0.30 | |||||
Elevated | 878/3784 | 35.8 (33.8 to 37.9) | 0.003 | 464/1746 | 39.7 (36.6 to 42.7) | 0.41 | 414/2038 | 32.7 (30.0 to 35.4) | 0.007 | |||||
75 years | ||||||||||||||
Optimal | 4/33 | 15.4 (1.3 to 29.5) | <0.001 | — | 1/5 | 25.0 (0.0 to 67.4) | 0.09 | — | 3/28 | 13.8 (0.0 to 28.3) | 0.003 | — | ||
Borderline | 87/492 | 23.6 (19.1 to 28.2) | 0.28 | 42/191 | 28.3 (20.6 to 36.1) | 0.85 | 45/301 | 20.6 (15.0 to 26.1) | 0.38 | |||||
Elevated | 685/2674 | 32.2 (30.0 to 34.3) | 0.02 | 315/1095 | 36.4 (33.0 to 39.9) | 0.51 | 370/1579 | 29.3 (26.7 to 32.0) | 0.03 |
Overall test comparing subhazard distributions across risk categories by Fine-Gray method. P<0.001 for interaction between sex and risk categories for index ages 55, 65, and 75 years.
Test comparing lifetime risk in borderline and elevated risk groups with optimal risk group by z ratio test (that is, difference in lifetime risk between two groups divided by its standard error).