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. 2018 Apr 19;9:414. doi: 10.3389/fphys.2018.00414

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Copyright © 2018 Boyle, Hakim, Zahid, Franceschi, Murphy, Vigmond, Dubois, Haïssaguerre, Hocini, Jaïs, Trayanova and Cochet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Workflow for comparison of RD_sim and RD_ECGI locations. Torso electrodes recorded 15 s of pre-ablation AF in PsAF patients (A), and unipolar electrograms were reconstructed (B). Phase maps (C) were analyzed to construct RD-phase singularity histograms (D). Each patient underwent LGE-MRI (E), which was used to reconstruct 3D atrial models (F). Programmed electrical stimulation induced in-silico AF (G), and fibrosis-driven RD-phase singularity trajectories in simulations were determined (H). RDs from ECGI and simulations were compared. Panel (A) is reused with permission from Cochet et al. (2018).