Table 2.
Associations between ERβ1 expression and other biological markers in female ERα‐negative PTC tissue specimens
| Biological markers | Positive percentage | P‐value | aTotal score | P‐value | Subcellular localization | P‐value | ||
|---|---|---|---|---|---|---|---|---|
| Nu | Nu+Cyto | Cyto | ||||||
| Ki‐67 | ||||||||
| − (n = 8) | 7 (87.5) | 0.309 | 5.50 ± 2.67 | 0.939 | 3 (42.9) | 3 (42.9) | 1 (14.3) | 0.130 |
| + (n = 62) | 60 (96.8) | 5.94 ± 1.56 | 8 (13.3) | 43 (71.7) | 9 (15.0) | |||
| E‐cadherin | ||||||||
| − (n = 14) | 12 (85.7) | 0.100 | 4.71 ± 2.33 | 0.008 | 2 (16.7) | 6 (50.0) | 4 (33.3) | 0.131 |
| + (n = 56) | 55 (98.2) | 6.18 ± 1.38 | 9 (16.4) | 40 (72.7) | 6 (10.9) | |||
| VEGF | ||||||||
| − (n = 14) | 14 (100.0) | 1.000 | 6.64 ± 0.84 | 0.056 | 4 (28.6) | 7 (50.0) | 3 (21.4) | 0.224 |
| + (n = 56) | 53 (94.6) | 5.70 ± 1.81 | 7 (13.2) | 39 (73.6) | 7 (13.2) | |||
PTC, papillary thyroid cancer; Nu, exclusively nuclear staining; Nu + Cyto, combined nuclear and cytoplasmic staining; Cyto, exclusively cytoplasmic staining.
a
Total score was calculated from the sum of the proportion staining score and intensity score to reflect the expression level, which is given as the mean ± S.D.