Figure 3.

Interplay between integrin trafficking and mTORC1 activity. α5β1 integrin promotes the trafficking of fibronectin (FN) to late endosomes (LEs)/lysosomes, resulting in the recruitment of the mechanistic target of rapamycin complex 1 (mTORC1) on the lysosomal membrane and the activation of downstream signalling. This pathway is strongly promoted by glucose deprivation. α6β4 mediates the lysosomal delivery and degradation of laminin (LN), similarly leading to mTORC1 recruitment and activation. This is stimulated by growth factor starvation. [Colour figure can be viewed at http://wileyonlinelibrary.com]