Table 1.

Residues found in the S₂ pocket of human cathepsin L and K (HsCatL, HsCatK) and adult F. hepatica CLs.

Protease	S2 pocket residues
	67	157	158	160	205
HsCatL	Leu	Met	Asp	Gly	Ala
HsCatK	Tyr	Leu	Asn	Ala	Leu
FhCL1	Leu	Val	Asn	Ala	Leu
FhCL2	Tyr	Leu	Thr	Ala	Leu
FhCL5	Leu	Leu	Asn	Gly	Leu

The residues mutated in this work are shown in bold italics. Residues were numbered according to papain numbering.