Figure 4.

lnc-31 Interacts with Rock1 mRNA and Mediates Its YB-1-Dependent Translation

Schematic representation of lnc-31 mode of action. In proliferating myoblasts (left), lnc-31 promotes the translation of Rock1 through the binding of its mRNA and the inhibition of proteasome-mediated YB-1 degradation. In myotubes (right), the poor levels of lnc-31 are not sufficient to sustain such activities leading to the downregulation of Rock1 expression. This loop would be further reinforced by the upregulation during myogenesis of miR-152, making it possible to establish robust negative control of Rock1 expression.