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. 2018 Apr 19;9:752. doi: 10.3389/fimmu.2018.00752

Figure 4.

Figure 4

Differentiation markers on CD161-expressing T cells. (A) Flow cytometric gating of naive cells (N; CD45RO−CCR7+), central memory cells (CM) (CD45RO+CCR7+), effector memory cells (EM) (CD45RO+CCR7−), and terminally differentiated cells (TD) (CD45RO−CCR7−) within the CD4+ and CD8+ T cell compartment of a young and old subject. (B) Percentages of differentiation subsets within the CD161-defined CD4+ T cell subsets of 20 young [of which 10 were cytomegalovirus (CMV) seropositive] and 44 old (of which 22 were CMV seropositive) subjects. (C) Percentages of differentiation subsets within the CD161-defined CD8+ T cell subsets of the same donors as mentioned at (B). Statistical significance by Mann–Whitney U-test is shown as *p < 0.05, **p < 0.01, or ***p < 0.001. Graphs in which CMV-seropositive young and old subjects are highlighted in the figures are shown in Figure S4 in Supplementary Material.