Figure 6.

Correlations and anti-correlations degraded in ADAD and ageing. (A) Comparing M+ CDR0 and M+ CDR1+, degraded positive correlations in ADAD (warm colours) outnumbered degraded anti-correlations (cool colours). Mirroring whole network connectivity patterns, the largest number and magnitude of degraded connections were within cognitive networks, particularly the default and dorsal attention networks. (B) Comparing young subjects to CNE AD−, the preferential degradation of positive connections in the default and dorsal attention networks was not evident, and more inter-network connections and anti-correlations were degraded with ageing as compared to ADAD. Map threshold P < 0.05.