Liraglutide promotes pancreatic β cell proliferation. (A, B) PCNA and Ki-67 mRNA expression levels in pancreatic tissues were detected by qRT-PC. (C) Western blot results of PCNA and Ki-67 protein are shown. (D, E) Quantification of the protein levels of PCNA and Ki-67 shown in C. (F, H) Representative images of IHC are shown (magnification 200×). (G, I) Quantification of PCNA and Ki-67-positive cells in F and H. Data are presented as mean ±SD (n=6). ** P<0.01 vs. control, *** P<0.001 vs. control, # P<0.05 vs. HFD + STZ group, ## P<0.01 vs. HFD + STZ.