Skip to main content
NCBI home page
Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1990 Dec;81(12):1195–1197. doi: 10.1111/j.1349-7006.1990.tb02676.x

Frequent Detection of Hepatitis C Virus US Strain in Japanese Hemophiliacs

Makoto Hijikata 1, Nobuyuki Kato 1, Shigehisa Mori 1, Yuko Ootsuyama 1, Masanori Nakagawa 1, Takashi Sugimura 1, Showgo Ohkoshi 2, Hideo Kojima 2, Takashi Meguro 3, Masashi Taki 3, Shigenobu Takayama 3, Kaneo Yamada 3, Kunitada Shimotohno 1,✉
PMCID: PMC5918019  PMID: 2177459

Abstract

Hemophiliacs have been found to be at high risk of hepatitis. Hemophiliacs in Japan receive imported clotting factors as well as domestic ones. Recently we found that hepatitis C virus (HCV) could be classified into at least two types, HCV‐US and HCV‐J, depending on the nucleotide sequence. We analyzed the nucleotide sequences of virus RNAs from the plasma of patients with hemophilia A or B and found HCV‐US in 3 of 4 Japanese hemophiliacs examined.

Keywords: Non‐A, non‐B hepatitis, Hepatitis C virus, Hemophilia, Transfusion, Clotting factors

Full Text

The Full Text of this article is available as a PDF (184.4 KB).

REFERENCES

  • 1. ) Choo , Q‐L. , Kuo , G. , Weiner , A. J. , Overby , L. R. , Bradley , D. W. and Houghton , M.Isolation of a cDNA clone derived from a blood borne non‐A, non‐B viral hepatitis genome . Science , 244 , 359 – 362 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 2. ) Kuo , G. , Choo , Q‐L. , Alter , H. J. , Gitnick , G. L. , Redeker , A. G. , Purcell , R. H. , Miyamura , T. , Dienstag , J. L. , Alter , M. J. , Stevens , C. E. , Tegtmeier , G. E. , Bonino , F. , Colombo , M. , Lee , W‐S. , Kuo , C. , Berger , K. , Shuster , J. R. , Overby , L. R. , Bradley , D. W. and Houghton , M.An assay for circulating antibodies to a major etiologic virus of human non‐A, non‐B hepatitis . Science , 244 , 362 – 364 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 3. ) Watanabe , J. , Minegishi , K. , Mitsumori , T. , Ishifuji , M. , Oguchi , T. , Ueda , M. , Tokunaga , E. , Tanaka , E. , Kiyosawa , K. , Furuta , S. , Katayama , T. , Kuo , G. , Choo , Q‐L. , Houghton , M. and Nishioka , K.Prevalence of anti‐HCV antibody in blood donors in the Tokyo area . Vox Sang ( 1990. ), in press . [DOI] [PubMed]
  • 4. ) Bruix , J. , Barrera , J. M. , Calvet , X. , Ercilla , G. , Costa , J. , Sanchez‐Tapias , J. M. , Ventura , M. , Vall , M. , Bruguera , M. , Bru , C. , Castillo , R. and Rodes , J.Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis . Lancet , ii , 1004 – 1006 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 5. ) Colombo , M. , Kuo , G. , Choo , Q‐L. , Donato , M. F. , Ninno , E. D. , Tommasini , M. A. , Dioguardi , N. and Houghton , M.Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma . Lancet , ii , 1006 – 1008 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 6. ) Ohkoshi , S. , Kojima , H. , Tawaraya , H. , Miyajima , T. , Kamimura , T. , Asakura , H. , Satoh , A. , Hirose , S. , Hijikata , M. , Kato , N. and Shimotohno , K.Prevalence of antibody against non‐A, non‐B hepatitis virus in Japanese patients with hepatocellular carcinoma . Jpn. J. Cancer Res. , 81 , 550 – 553 ( 1990. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7. ) Kaneko , S. , Unoura , M. , Kobayashi , K. , Kuno , K. , Murakami , S. and Hattori , N.Detection of serum hepatitis C virus RNA . Lancet , 335 , 976 ( 1990. ). [DOI] [PubMed] [Google Scholar]
  • 8. ) Ohkoshi , S. , Kato , N. , Kinoshita , T. , Hijikata , M. , Ohtsuyama , Y. , Okazaki , N. , Ohkura , H. , Hirohashi , S. , Honma , A. , Ozaki , T. , Yoshikawa , A. , Kojima , H. , Asakura , H. and Shimotohno , K.Detection of hepatitis C virus RNA in sera and liver tissues of non‐A, non‐B hepatitis patients using the polymerase chain reaction . Jpn. J. Cancer Res. , 81 , 862 – 865 ( 1990. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9. ) Kato , N. , Ohkoshi , S. and Shimotohno , K.Japanese isolates of non‐A, non‐B hepatitis viral genome show the sequence variations from the original isolate in the USA . Proc. Jpn. Acad. , 65B , 219 – 223 ( 1989. ). [Google Scholar]
  • 10. ) Esteban , J. I. , Esteban , R. , Viladomiu , L. , López‐Talavera , J. C. , González , A. , Hernández , J. M. , Roget , M. , Vargas , V. , Genescá , J. , Buti , M. and Guardia , J.Hepatitis C virus antibodies among risk groups in Spain . Lancet , ii , 294 – 297 ( 1989. ). [DOI] [PubMed] [Google Scholar]
  • 11. ) Noel , L. , Guerois , C. , Maisonneuve , P. , Verroust , F. and Laurian , Y.Antibodies to hepatitis C virus in haemophilia . Lancet , ii , 560 – 562 ( 1989. ). [Google Scholar]
  • 12. ) Houghton , M. , Choo , Q‐L. and Kuo , G.Eur. Patent Appl. , 88 , 310 , 922.5 and publ. 318 , 216 ( 1988. ). [Google Scholar]
  • 13. ) Kato , N. , Hijikata , M. , Ootsuyama , Y. , Nakagawa , M. , Ohkoshi , S. and Shimotohno , K.Sequence diversity of hepatitis C virus genomes . Mol. Biol. Med. ( 1990. ), in press . [PubMed]
  • 14. ) Garson , J. A. , Preston , F. E. , Makris , M. , Tuke , P. , Ring , C. , Machin , S. J. and Tedder , R. S.Detection by PCR of hepatitis C virus in factor VIII concentrates . Lancet , 335 , 1473 ( 1990. ). [DOI] [PubMed] [Google Scholar]
  • 15. ) Fletcher , M. L. , Trowell , J. M. , Craske , J. , Pavier , K. and Rizza , C. R.Non‐A, non‐B hepatitis after transfusion of factor VIII in infrequently treated patients . Br. Med. J. , 287 , 1754 – 1757 ( 1983. ). [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Japanese Journal of Cancer Research : Gann are provided here courtesy of Wiley

RESOURCES