Table 2. Antiviral monoclonal antibodies in clinical development.

PowerPoint slide

Antibody	Virus	Antibody isolation technology	Target	Stage of development	Manufacturer	Indication
Porgaviximab	Ebola virus	Immunization and chimerization	Viral Env glycoprotein	Phase I and II	Mapp Biopharmaceutical; LeafBio	Treatment of Ebola virus infection after exposure
MBL HCV1	HCV	Humanized mice	HCV E2 glycoprotein	Phase II	MassBiologics	Prevention of HCV recurrence in patients receiving a liver transplant
PRO 140	HIV	Immunization and humanization	CCR5	Phase III	Progenics Pharmaceuticals	Treatment of HIV-1 infection
Ibalizumab	HIV	Immunization and humanization	CD4	Phase III	TaiMed Biologics	Treatment of HIV-1 infection
UB 421	HIV	Immunization and humanization	CD4	Phase II	United Biomedical	Treatment of HIV-1 infection
VRC01-LS	HIV	Human B cell isolation	HIV gp120	Phase I	National Institute of Allergy and Infectious Diseases	Prevention of HIV-1 infection
VRC01	HIV	Human B cell isolation	HIV gp120	Phase I	National Institute of Allergy and Infectious Diseases	Treatment of HIV-1 infection
3BNC117-LS	HIV	Human B cell isolation	HIV gp120	Phase I	Rockefeller University	Treatment of HIV-1 infection
10-1074 and 3BNC117	HIV	Human B cell isolation	HIV gp120	Phase I	Rockefeller University	Treatment of HIV-1 infection
PGT121	HIV	Human B cell isolation	HIV gp120	Phase I	International AIDS Vaccine Initiative	Treatment and prevention of HIV-1 infection
PGDM1400 and PGT121	HIV	Human B cell isolation	HIV gp120	Phase I	International AIDS Vaccine Initiative	Treatment and prevention of HIV-1 infection
MB 66	HIV and HSV	Human B cell isolation	HIV gp120 and HSV glycoprotein D	Phase I	Mapp Biopharmaceutical	Prevention of HIV-1 and HSV sexual transmission
VIS 410	Influenza virus	Unknown	Influenza virus HA	Phase II	Visterra	Treatment and prevention of influenza A virus infection
MHAA 4549A	Influenza virus	Human B cell isolation	Influenza virus HA	Phase II	Genentech	Treatment of influenza A virus infection
CT P27	Influenza virus	Human B cell isolation	Influenza virus HA	Phase II	Celltrion	Treatment and prevention of influenza A virus infection
Diridavumab	Influenza virus	Phage display	Influenza virus HA	Phase II	National Institute of Allergy and Infectious Diseases	Treatment and prevention of influenza A virus infection
CR8020	Influenza virus	Human B cell isolation	Influenza virus HA	Phase II	Crucell	Treatment and prevention of influenza A virus infection
RG 6024	Influenza virus	Human B cell isolation	Influenza virus HA	Phase I	Genentech	Treatment of influenza B virus infection
MEDI 8852	Influenza virus	Human B cell isolation	Influenza virus HA	Phase II	MedImmune	Treatment of influenza A virus infection
TCN 032	Influenza virus	Human B cell isolation	Influenza virus M2e protein	Phase II	Theraclone Sciences; Zenyaku Kogyo	Treatment of influenza A virus infection
m 102.4	Nipah and Hendra virus	Phage display	Viral Env glycoprotein G	Phase I	Profectus Biosciences, Inc.	Prevention and treatment of Nipah and Hendra virus infections
Rabimabs	Rabies virus	Immunization	Viral Env G protein	Phase I and II	World Health Organization; Zydus Cadila	Treatment and prevention of rabies
RAB-1	Rabies virus	Humanized mice	Viral Env G protein	Approved	Serum Institute of India; MassBiologics	Prophylaxis after exposure to rabies
Foravirumab	Rabies virus	Phage display, human B cell isolation	Viral Env G protein	Phase II and III	Crucell; Sanofi Pasteur	Prophylaxis after exposure to rabies
Palivizumab	RSV	Immunization and humanization	Viral fusion protein	Approved	MedImmune	Prophylaxis in high-risk infants
MEDI 8897	RSV	Human B cell isolation	Viral fusion protein	Phase II	MedImmune	Prophylaxis in all infants

CCR5, CC-chemokine receptor 5; E2, envelope glycoprotein (HCV); Env, envelope; gp120, envelope glycoprotein gp120; HA, haemagglutinin; HCV, hepatitis C virus; HSV, herpes simplex virus; M2e, matrix protein 2 (influenza virus); RSV, respiratory syncytial virus.