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. 2018 Mar 10;9:257–269. doi: 10.1016/j.omtm.2018.03.002

Figure 2.

Figure 2

Correction of the SCID-X1 Phenotype in Il2rg-Deficient Mice

(A–C) Reconstitution of T, B, NK, and myeloid cells in the bone marrow (A), peripheral blood (B), and spleen and thymus (C) of Rag2−/−/Il2rg−/− mice transplanted with wild-type C56Bl6 Lin− cells transduced with a PGK-GFP vector (WT + PGK-GFP), Il2rg−/− Lin− cells transduced with the PGK-GFP vector (KO + PGK-GFP), and Il2rg−/− Lin− cells transduced with the EFS-IL2RG vector (KO + EFS-IL2RG), 6 months after transplantation. Data are presented as individual animals and as means ± SEM. Statistical differences are expressed as follows: n.s., non-significant; **p < 0.01, ***p < 0.001, and ****p < 0.0001.