Abstract
A total of 129 consecutive gastrectomy specimens from Japanese (99), Philippinos (11), Hawaiians (8), Koreans (5), Chinese (4) and Caucasians born in Hawaii (2) were examined under high‐power light microscopy (1000X) for the presence of ciliated gastric cells. Fifty‐two of the 129 gastrectomy specimens (40.3%) contained ciliated cells. Ciliated cells were found in the hasal segments of antral glands (usually cystically dilated) whose superficial segments had undergone intestinal metaplasia. The presence of ciliated cells in the gastric mucosa was influenced by the age of the patient and by the degree of intestinal metaplasia: the older the patient, the greater the degree of intestinal metaplasia and the greater the frequency of specimens with ciliated cells. The presence of ciliated cells was also influenced by the type of lesion in the specimen. Although the highest frequency (47.2%) was found in stomachs removed for adenocarcinoma, a substantial number of stomachs removed for gastric ulcer also showed that change (36%). The data suggest that increasing age and advanced atrophic gastritis, especially of the antrum, provide the necessary conditions that lead to the development of cilia, not only in Japanese subjects, but in other Hawaiian ethnic groups as well.
Keywords: Gastric mucosa, Ciliated cells
Full Text
The Full Text of this article is available as a PDF (258.4 KB).
REFERENCES
- 1. ) Kodaira , T. , Watanabe , Y. and Arimori , M.Ciliated epithelium in gastric mucosa observed in chronic gastritis. An electron microscopic study Proc. Jpn. Cancer Assoc., 33rd Annu. Meet. , 184 ( 1974. ).
- 2. ) Okuda , T. and Ogata , T.An electron microscopic study of the ciliated cells in the human gastric mucosa . Arch. Histol Jpn. , 39 , 149 – 156 ( 1976. ). [DOI] [PubMed] [Google Scholar]
- 3. ) Yamashiro , K. , Suzuki , H. and Nagayo , T.Electron microscopy of a ciliated cell in the human stomach . Beitr. Pathol. , 160 , 401 – 406 ( 1977. ). [DOI] [PubMed] [Google Scholar]
- 4. ) Kato , Y. , Sugano , H. and Rubio , C. A.Classification of intramucosal cysts of the stomach . Histopathology , 7 , 931 – 938 ( 1983. ). [DOI] [PubMed] [Google Scholar]
- 5. ) Stemmermann , G. N. , Hayashi , T. and Teruya , S.The dysplastic nature of intestinal metaplasia in the stomach . In “ Precursors of Gastric Cancer ,” ed. Ming S. C. , pp. 155 – 166 ( 1984. ). Praeger Publishers; , New York . [Google Scholar]
- 6. ) Rubio , C. A. and Kato , Y.Ciliated metaplasia in the gastric mucosa. Studies on Japanese patients . Jpn. J. Cancer Res. , 77 , 282 – 286 ( 1986. ). [PubMed] [Google Scholar]
- 7. ) Torikata , C. , Mukai , M. and Kawakita , H.Ciliated cells in the human gastric mucosa. Evidence of metaplastic change . Jpn. Soc. Pathol. , 40 , 98 – 106 ( 1990. ). [DOI] [PubMed] [Google Scholar]
- 8. ) Rubio , C. A. , and Serck‐Hanssen , A.Ciliated metaplasia in the gastric mucosa. II. In a European patient with gastric carcinoma . PathoL Res. Pract. , 181 , 382 – 384 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 9. ) Rubio , C. A.Ciliated metaplasia in a gastric adenoma in a Swedish patient . APMIS , 96 , 895 – 897 ( 1988. ). [DOI] [PubMed] [Google Scholar]
- 10. ) Rubio , C. A. and Antonioli , D.Ciliated metaplasia in the gastric mucosa in an American patient . Am. J. Surg. Pathol. , 12 , 786 – 789 ( 1988. ). [DOI] [PubMed] [Google Scholar]
- 11. ) Stemmermann , G. N. and Hayashi , T.Intestinal metaplasia of the gastric mucosa: a gross and microscopic study of its distribution in various disease states . J. Natl. Cancer Inst. , 41 , 627 – 634 ( 1968. ). [PubMed] [Google Scholar]
- 12. ) Nomura , A. , Stemmermann , G. N. and Heilbrunn , L. K.Gastric cancer among the Japanese in Hawaii: a review . Hawaii Med. J. , 44 , 301 – 303 ( 1985. ). [PubMed] [Google Scholar]
- 13. ) Stemmermann , G. N. , Ishidate , T. , Samloff , M. , Masuda , H. , Walsh , J. H. , Nomura , A. , Yamakawa , H. and Glober , G.Intestinal metaplasia of the stomach in Hawaii and Japan. A study of its relation to serum pepsinogen I, gastrin and parietal cell antibodies . Am. J, Dig, Dis. , 23 , 815 – 820 ( 1978. ). [DOI] [PubMed] [Google Scholar]
- 14. ) Rubio , C. A. , Kato , Y. , Kitagawa , T. , Sugano , H. and Grimelius , L.Intramucosal cysts of the stomach. VIII: Histochemical studies . APMIS , 96 , 627 – 634 ( 1988. ). [DOI] [PubMed] [Google Scholar]
- 15. ) Rubio , C. A. , Kato , Y. and Sugano , H.The intramucosal cysts of th stomach. VI. Their quantitative and qualitative characteristics in focal (elevated) neoplastic lesions , Pathol Res. Pract. , 179 , 105 – 109 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 16. ) Rubio , C. A. , Hayashi , T. and Stemmermann , G.N.Ciliated gastric cells: a study of their phenotypic characteristics Mod. Pathol. , 6 ( 1990. ), in press . [PubMed] [Google Scholar]