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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Stem Cells. 2018 Feb 14;36(5):796–806. doi: 10.1002/stem.2796

Figure 1. TLR4 −/− MSCs show increased susceptibility to cell death when exposed to cytotoxic stimuli in vitro.

Figure 1

After exposure to TNF-α (100 ng/ml) and cycloheximide (20 µg/ml) (TNF/CHX), TLR4 −/− MSC showed significantly higher caspase 3/7 activity (A) and a significant reduction in monolayer resistance (B, C) (panel A, **p < 0.01 WT vs TLR4 −/− MSC, n = 6 per group; panel B and C, **p < 0.01 TLR4 −/− MSC + TNF/CHX vs unstim TLR4 −/− MSC and WT MSC + TNF/CHX, n = 4 per group).