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Equilibrium Solubility of Azithromycin in Various Formulations (Mean ± SD, n = 4)
| Formulation | Azithromycin solubility (mg/mL) at 37°C |
|---|---|
| Azithromycin-Raw | 1.0 ± 0.1 |
| L-leucine-Azithromycin_1–1_Physical Mixture | 1.1 ± 0.1 |
| L-leucine-Azithromycin_4–1_Physical Mixture | 1.3 ± 0.1 |
| Azithromycin-SD | 1.0 ± 0.1 |
| L-leucine-Azithromycin_1–1 | 1.3 ± 0.1 |
| L-leucine-Azithromycin_4–1 | 1.8 ± 0.2 |
