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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: J Pain. 2017 Apr 27;18(9):1046–1059. doi: 10.1016/j.jpain.2017.04.001

Figure 2.

Figure 2

Inadequate pain relief correlated with OPRM1 hypermethylation and was unrelated to opioid dosage. (A) No relationship was found between opioid use (x-axis) versus pain relief (y-axis), as shown by this regression plot with r2 = .02. (B) Patients were divided according to their pain relief score into those that had inadequate pain relief (≤20) or those that had near total pain relief (≥90). Patients with inadequate pain relief had significantly higher methylation values in the −232 to +109 amplicon than patients with near total pain relief (P < .001, 2-way ANOVA, Holm-Sidak post hoc test; Table 1).