Online Resource 1.
“Dopamine movies” of DA activation for individual representative female (top) and male (bottom) smokers while smoking. The value at each voxel over time is the output of the lp-ntPET model. Four contiguous 2 mm coronal slices through the ventral striatum are shown for both subjects. Smoking started at 45 min. relative to injection of the tracer (0 min). The movie is comprised of 3 min frames from 25 min before smoking to end of scan. The color of the activation represents percentage increase in DA relative to baseline; percentage above baseline ranges from 0–150% (cool to hot colors). Note presence of activation in right ventral striatum in male, but not in female. The ventral activation in the male peaks from 65–70 min. The activation in the female is only in the dorsal striatal areas. Right side of brain is on the right. (MP4 263 KB)