Table 2.
SNPs Upstream of the CHRNB4 Gene Are Associated with CHRNB4 Gene Expression in Islets from Human Donors
| SNP | chr (hg19) |
Position (hg19) |
p Value | FDR | GWAS Hit for Type 2 Diabetes and/or Glycemic Traits (p Value < 0.05)? |
Islet Regulome TF-Binding Sites |
|---|---|---|---|---|---|---|
| Chr15:78942385D | chr15 | 78 942 385 | 1.87E–05 | 0.00861 | ||
| rs12910237 | chr15 | 78 956 338 | 1.98E–05 | 0.009019 | MAGIC_2hrGlucose_AdjustedForBMI + DIAGRAM_T2D | |
| rs12915539 | chr15 | 78 940 795 | 2.05E–05 | 0.009252 | ||
| rs1021070 | chr15 | 78 946 863 | 2.07E–05 | 0.009323 | DIAGRAM_T2D | |
| rs7181405 | chr15 | 78 948 152 | 2.15E–05 | 0.009608 | DIAGRAM_T2D | |
| rs922691 | chr15 | 78 963 994 | 2.85E–05 | 0.011931 | DIAGRAM_T2D | NKX6.1,NKX2.2 |
| rs58946838 | chr15 | 78 961 449 | 2.87E–05 | 0.012026 | ||
| rs61630816 | chr15 | 78 965 866 | 5.44E–05 | 0.019905 | ||
| rs34694149 | chr15 | 78 965 917 | 5.44E–05 | 0.019905 | ||
| rs12905641 | chr15 | 78 964 362 | 6.16E–05 | 0.021855 | MAGIC_2hrGlucose_AdjustedForBMI + DIAGRAM_T2D | |
| rs34275594 | chr15 | 78 981 282 | 6.44E–05 | 0.022621 | ||
| rs7178007 | chr15 | 78 965 254 | 6.46E–05 | 0.022671 | ||
| rs8038920 | chr15 | 78 974 545 | 6.88E–05 | 0.023829 | DIAGRAM_T2D |
Transcription factor (TF)-binding sites were obtained from the human islet regulome database (http://gattaca.imppc.org/isletregulome/regulome/cgi-bin/regulome.cgi). FDR, false discovery rate; GWAS, genome-wide association study.