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. Author manuscript; available in PMC: 2018 Apr 27.
Published in final edited form as: Nat Genet. 2018 Feb 26;50(3):381–389. doi: 10.1038/s41588-018-0059-2

Table 2.

Functional gene set analysis highlights six independent gene sets associated with schizophrenia

Gene set Number of genes Enrichment P value (FWER)a Conditional P valueb
Targets of FMRP32 798 1×10−5 1.9×10−8
Abnormal behavior (MP:0004924) 1,939 1.8×10−4 1.4×10−5
5-HT2C receptor complex37 16 0.029 0.001
Abnormal nervous system electrophysiology (MP:0002272) 201 0.003 0.002
Voltage-gated calcium channel complexes36 196 0.011 0.016
Abnormal long-term potentiation (MP:0002207) 142 0.030 0.031

MP refers to Mammalian Phenotype Ontology terms of the MGI35, from which gene sets were derived. FMRP, fragile X mental retardation protein.

a

Westfall-Young family-wise error rate, as implemented in MAGMA20.

b

From stepwise conditional analysis that adjusts sequentially for ‘stronger’ associated gene sets.