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. 2018 Apr 26;16:110. doi: 10.1186/s12967-018-1483-x

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — In vitro cytotoxicity and viral replication of chimeric orthopoxvirus CF33-Fluc in pancreatic cancer cell lines. Viability of pancreatic cancer cell lines BxPC-3, PANC-1, MIA PaCa-2, SU.86.86, AsPC-1 and Capan-1 was assessed daily for 8 days after infection with CF33-Fluc. Percent cell survival over time is shown at MOI^† = 1 (a), MOI = 0.1 (b), and MOI 0.01 (c). Dose-dependent cell killing was seen in all cell lines. d Viral proliferation was inversely correlated to the LD50^‡ in PANC-1, SU.86.86, AsPC-1 and Capan-1 (R² = 0.932). (^†MOI, multiplicity of infection. ^‡LD50, lethal dose for 50% cell killing)