Fig 6. IL therapy with PV-10 in combination with anti-PD-L1 antibodies leads to delayed growth of treated and bystander B16 tumors.

Mice received 1x10⁵ B16 tumor cells SC on bilateral flanks on Day 0. On Day 7, right flank tumors were injected with 50 μl PV-10 or PBS IL. Mice received 300 μg anti-PD-L1 or NrIgG antibodies beginning on Day 8 and continuing 2x/week until mice had reached endpoint. Combination of PV-10 and anti-PD-L1 led to a delayed tumor growth in A) B16 tumors treated with IL PV-10 and B) untreated B16 bystander tumors.