Table 4. Panel A. Univariable analysis showing the independent association of each parameter with survival.

Panel B. Multivariable analysis showing those that remained in the model.

Panel A. Univariable analysis exploring factors that predict survival
Variables	HR (95% IC)	p value
Age (for each year)	1.09 (1.05–1.13)	0.001
Pack-year (for each pack-year)	1.00 (1.01–1.02)	0.06
BMI (index)	1.00 (0,94–1,07)	0.80
Gender (male as reference)	0.45 (0.18–1.16)	0.10
Current Smoker (yes vs. no)	2.12 (1.02–4.39)	0.04
FEV1% (for each %)	0.97 (0.96–0.99)	0.001
MMRC (for each point)	1.36 (1.07–1.70)	0.01
6MWD (for each m)	0.99 (0.98–0.99)	0.001
BODE (for each point)	1.19 (1.04–1.35)	0.007
Pulmonary Artery diameter (for each mm)	1.19 (1.12–1.27)	0.001
Pulmonary Artery diameter≥30mm (yes vs. no)	4.52 (2.28–8.98)	0.001
Pulmonary artery quartiles (reference Q1)
Q2 vs Q1	0.94 (0.32–2.71)	0.90
Q3 vs Q1	1.26 (0.62–4.22)	0.32
Q4 vs Q1	5.36 (2.33–12.32)	0.001
Emphysema (yes vs no)	0.88 (0.48–1.63)	0.69
Panel B. Multivariable analysis
Variables	HR (95%IC)	p value
Age (for each year)	1.08 (1.04–1.13)	0.001
Pulmonary Artery diameter≥30mm (yes vs no)	2.78 (1.35–5.75)	0.006

Variables included in the model: age, BSA, current smoker, BODE, Pulmonary Artery diameter>30mm