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. 2018 Apr 25;18:466. doi: 10.1186/s12885-018-4346-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Assessment of epigenetic drug-mediated sensitization of cytarabine resistant cells. Proliferation of Z138-CytR cells exposed to different concentrations of six epigenetic drugs for 6 hours, prior to addition of 50 μM cytarabine. Several epigenetic drugs showed a tendency to re-sensitize Z138-CytR to cytarabine, at the lowest concentration (0.1 μM). Each data point represents mean relative proliferation ± SEM of three independent experiments. * = p < 0.05 and ** = p < 0.01, using students unpaired t-test. The data, collected 30 h after treatment, are normalized to the 0-h time-point and the R10 medium control (+/− cytarabine)