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. 2018 Apr 25;19:293. doi: 10.1186/s12864-018-4676-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — An evolutionary model of the GSTM1 deletion in humans and chimpanzees. Based on our results, we built a model to describe the mutational events through evolutionary time: (a) Gene conversions occurred between SD1 and SD2 before the divergence of humans and chimpanzees. (b) The GSTM1 gene was deleted in both human and chimpanzee lineages with very similar breakpoints. (c) A chimpanzee-specific sequence exchange between the SD1 and SD2 occurred