Fig 1. The nuclear pore complex is important for Ty retrotransposition.

Left. A generic schematic of the lifecycle of a Ty. Chromosomal copies of Ty, found in the yeast genome, produce full-length RNA transcripts that are exported from the nucleus. These transcripts are translated and also packaged within virus-like particles within the cytoplasm. Packaged RNAs are reverse transcribed into cDNA that is transported into the nucleus via the nuclear pore complex. The Ty integrase mediates insertion of the cDNA into the host genome at a new location (red stripes on the chromosome). Right. Simplified representation of the nuclear pore complex embedded in the nuclear envelope and sliced along its vertical axis. Filaments rich in phenylalanine and glycine (FG) radiate into the nucleoplasm, cytoplasm, and within the nuclear pore itself.