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Up-regulation of miR-449a expression by ABDHFA treatment targeted AR expression. ABDHFA promoted miR-449a expression in TCCSUP and TCCSUP bladder cancer cells and inhibited AR level. Transfection of lentivirus markedly increased miR-449a expression in bladder cancer cells, which subsequently reduced PSA level. The miR-449a up-regulation by lentivirus reduced expression of AR protein.
