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. Author manuscript; available in PMC: 2018 Apr 27.
Published in final edited form as: Lab Invest. 2014 Jul 28;94(9):1030–1041. doi: 10.1038/labinvest.2014.85

Figure 6.

Figure 6

Expression pattern of wound healing-related genes in an alkali-burned cornea. (a) Expression of interleukin-6 (IL-6) is transiently increased at 5 days in the healing alkali-burned wild-type (WT) corneas, but then decreased. Lacking transient receptor potential ankyrin 1 (TRPV1) abolishes the IL-6 mRNA expression peak. (b) Expression of vascular endothelial growth factor (VEGF) was transiently increased at 10 days in the healing alkali-burned WT corneas but then decreased. Lacking TRPA1 abolished the VEGF mRNA expression peak. (c) Expression of collagen Ia1 mRNA increases at 5 days in the healing alkali-burned WT corneas, and declines due to TRPA1 loss. (d) Expression of Substance P (SP) increased markedly at 20 days in the healing alkali-burned WT corneas, but was later suppressed, which is associated with TRPA1 loss in the healing alkali-burned mouse corneas at this time point. Data represent mean±s.e.m. from five specimens in each condition (bar). *P<0.05.