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. Author manuscript; available in PMC: 2018 Apr 27.
Published in final edited form as: Lab Invest. 2014 Jul 28;94(9):1030–1041. doi: 10.1038/labinvest.2014.85

Figure 7.

Figure 7

Healing an alkali-burned cornea in a bone marrow transplanted (BMT) mouse. (a) A total of 10 and 20 days after alkali burning, a wild-type (WT) mouse that had received bone marrow (BM) from a WT mouse (WT-to-WT) and a WT mouse that had received BM from a TRPA1-null (KO) mouse (KO-to-WT) exhibited greater opacification and neovascularization as compared with those by the KO mouse that had received BM from a WT mouse (WT-to-KO) group. (b) HE histology shows increases in cell density in the swollen stroma of a KO-to-WT cornea as compared with a WT-to-KO tissue. Immunohistochemistry indicated the cornea of a WT-to-KO mouse has less stromal α-SMA staining and lower levels of immunoreactivity for MPO, F4/80, and active TGF-β1 as compared with the KO-to-WT tissue. Scale bar, 100 μm.