Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 15;10(3):875–889. doi: 10.1016/j.stemcr.2018.01.009

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Model of HOXB4 Activity during Pluripotent Stem Cell Differentiation

During mouse ESC differentiation, HOXB4 appears to promote hematopoietic commitment after the hemangioblast stage in VE-Cad⁺FLK-1⁺TIE2⁺KIT⁺CD31⁺ precursors of HE cells by upregulating the expression of key hematopoietic transcription factors, in a RUNX1-independent fashion. Importantly, our results indicate that this does not happen at the expense of endothelial cells. These results are also compatible with the notion that (at least a part of) endothelial cells develop hemangioblast-independently (Padron-Barthe et al., 2014, Ueno and Weissman, 2006).