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. 2018 Mar 1;10(3):834–847. doi: 10.1016/j.stemcr.2018.01.039

Figure 5.

Figure 5

Metabolic Ability of 2D CMs and 3D CMs

(A) Beating rate for hiPSC-CMs of both control cell lines in 2D.

(B) Beating rate and contractile force for hiPSC-CMs of both control cell lines in 3D in feeding medium containing only one energy source for 20 hr, 1 mM fatty acid, 1 mM lactate, 5 mM glucose, or no energy substrate.

(C–E) Normalized force development (C) and original recordings (D and E) of 3D hiPSC-CMs during 100 min of hypoxia treatment (gray box) and reoxygenation.

n denotes biological replicates from three independent experiments of both control cell lines; error bars show means ± SEM. Related data are depicted in Figure S5 and Movie S2.