Table 3. Probabilities of randomness of the observed amino acid enrichment in selected internal or flanking positions of HLA-B*08:01 epitopes.

Nomenclature of positions is as in Fig 8. Probabilities (p) were calculated by Fisher's exact test. No correction for multiple testing was performed.

position	amino acid	occurrence in epitopes	occurrence in non-epitopes		p
N7	L	6	28		0.0048
	other	10	255
C1	L	12	108		0.0067
	other	4	175
N2'	K	4	14		0.0107
	other	12	269
N2'	RKH	6	35		0.0129
	other	10	248
N2'	RKHCSTNQ	13	108		0.0010
	other	3	175
N1'	E	4	13		0.0086
	other	12	270
C1'	S	6	22		0.0016
	other	10	261
C1'	CSTNQ	10	59		0.0006
	other	6	224
C1'	RKHCSTNQ	12	104		0.0032
	other	4	179
C2'	K	5	13		0.0013
	other	11	270
C2'	RKH	7	39		0.0050
	other	9	244