Table 3. The results of the univariate and multivariate analyses of the prognostic factors for relapse-free survival.

	Univariate			Multivariate
	OR	95%CI	p-value	OR	95%CI	p-value
Sex (male)	1.881	1.029–3.561	0.0442	2.223	1.176–4.345	0.0137
Age (≥67years)	2.201	1.187–4.286	0.0118	2.556	1.345–5.079	0.0039
Tumor location (Rectum)	1.115	0.614–2.024	0.7186
Tumor size (≥4cm)	0.962	0.530–1.746	0.8989
Depth of tumor (T4)	1.030	0.529–1.910	0.9275
Lymphatic vessel invasion (positive)	2.362	1.074–6.233	0.0313	1.219	0.506–3.404	0.6734
Venous invasion (positive)	1.721	0.851–3.256	0.1256
Lymph node metastasis (positive)	2.389	1.313–4.472	0.0043	1.944	0.989–3.930	0.0539
Preoperative CEA level (≥5ng/ml)	1.740	0.951–3.150	0.0718	0.774	0.357–1.588	0.4918
Preoperative CA19-9 level (≥ 37U/ml)	3.837	1.826–7.505	0.0008	3.967	1.667–9.137	0.0023
The density of TILs (High)	2.585	1.177–6.813	0.0160	2.342	1.031–6.311	0.0414

OR, odds ratio; CI, confidence interval; CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19–9; TILs, tumor infiltrating lymphocytes