Table 3. Clinical factors at initial colonoscopy predictive of any missed adenoma of repeat colonoscopy.
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| No adenoma | Any adenoma at repeat colonoscopy | P | OR | 95% CI | P | |
| Age at initial colonoscopy | < 0.001 | |||||
| < 60 | 147 (66.8) | 73 (33.2) | (ref) | |||
| ≥ 60 | 107 (48.4) | 114 (51.6) | 1.53 | 0.97–2.41 | 0.065 | |
| Sex | 0.110 | |||||
| Female | 86 (63.2) | 50 (36.8) | (ref) | |||
| Male | 168 (55.1) | 137 (44.9) | 0.99 | 0.58–1.69 | 0.970 | |
| BMI | 0.026 | |||||
| < 25 | 160 (62.0) | 98 (38.0) | (ref) | |||
| ≥ 25 | 94 (51.4) | 89 (48.6) | 1.55 | 1.00–2.40 | 0.049 | |
| Smoking | 0.565 | |||||
| Never | 165 (59.6) | 112 (40.4) | (ref) | |||
| Ex-smoker | 40 (54.1) | 34 (45.9) | 0.71 | 0.36–1.41 | 0.330 | |
| Current | 49 (54.4) | 41 (45.6) | 1.00 | 0.54–1.87 | 0.992 | |
| Alcohol intake | 0.028 | |||||
| No | 141 (62.7) | 84 (37.3) | (ref) | |||
| Social & heavy | 113 (52.3) | 103 (47.7) | 1.26 | 0.75–2.11 | 0.387 | |
| Family history of CRC | 0.156 | |||||
| No | 249 (58.2) | 179 (41.8) | (ref) | |||
| Yes | 5 (38.5) | 8 (61.5) | 2.38 | 0.69–8.17 | 0.168 | |
| History of colon polyp | < 0.001 | |||||
| No | 193 (63.3) | 112 (36.7) | (ref) | - | ||
| Yes | 61 (44.9) | 75 (55.1) | 1.98 | 1.23–3.19 | 0.005 | |
| Hypertension | < 0.001 | |||||
| No | 191 (63.9) | 108 (36.1) | (ref) | |||
| Yes | 63 (44.4) | 79 (55.6) | 1.52 | 0.93–2.49 | 0.097 | |
| Diabetes mellitus | 0.023 | |||||
| No | 217 (60.1) | 144 (39.9) | (ref) | |||
| Yes | 37 (46.2) | 43 (53.8) | 1.09 | 0.60–1.96 | 0.777 | |
| Dyslipidemia | 0.007 | |||||
| No | 239 (59.6) | 162 (40.4) | (ref) | |||
| Yes | 15 (37.5) | 25 (62.5) | 1.94 | 0.88–4.29 | 0.102 | |
| Arterial thromboembolic diseasea | 0.001 | |||||
| No | 249 (59.3) | 171 (40.7) | (ref) | |||
| Yes | 5 (23.8) | 16 (76.2) | 3.46 | 1.09–11.02 | 0.036 | |
| Initial colonoscopy finding | < 0.001 | |||||
| No adenoma | 134 (71.7) | 53 (28.3) | (ref) | |||
| Low-risk adenomab | 78 (54.9) | 64 (45.1) | 2.03 | 1.23–3.36 | 0.006 | |
| High-risk adenomac | 42 (37.5) | 70 (62.5) | 4.19 | 2.36–7.44 | < 0.001 | |
| Intervald | 0.395 | |||||
| < 13 month | 120 (55.6) | 96 (44.4) | (ref) | |||
| ≥ 13 month | 134 (59.6) | 91 (40.4) | 0.95 | 0.61–1.46 | 0.806 | |
| Out-patients | 0.691 | |||||
| No | 50 (59.5) | 34 (40.5) | (ref) | |||
| Yes | 204 (57.1) | 153 (42.9) | 1.17 | 0.65–2.12 | 0.603 | |
| Endoscopists’ experience | 0.623 | |||||
| Expert | 138 (56.6) | 106 (43.4) | (ref) | |||
| Trainee | 116 (58.9) | 81 (41.1) | 1.36 | 0.87–2.12 | 0.178 | |
| Indication for initial colonoscopy | 0.900 | |||||
| Screen or surveillance | 208 (57.5) | 154 (42.5) | (ref) | |||
| Diagnostic or therapeutic | 46 (58.2) | 33 (41.8) | 1.05 | 0.58–1.90 | 0.881 | |
| Withdrawal time | 0.018 | |||||
| < 6 minutes | 48 (70.6) | 20 (29.4) | (ref) | |||
| ≥ 6 minutes | 206 (55.2) | 167 (44.8) | 1.28 | 0.67–2.45 | 0.458 | |
BMI, body mass index; CRC, colorectal cancer; OR, odds ratio; CI, confidence interval.
aArterial thromboembolic disease included ischemic heart disease or stroke.
bLow-risk adenoma group was defined as 1 or 2 tubular adenoma without feature of advanced adenoma.
cHigh-risk adenoma group included advanced adenomas or more than 3 tubular adenomas without the feature of advanced adenoma.
dInterval means the duration from the initial to repeat colonoscopy, and the median was 13 months.