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The degeneration of nigrostriatal dopaminergic projections on the dorsal striatum was achieved through stereotaxic injection of the toxin 6-hydroxydopamine (6-OHDA) at postnatal day 21 (PND21). After recovery, rats were chronically administered with the DA agonist quinpirole that induced a tic-like motor phenotype that was quantified on PND48 and used for drug testing. The entire experimental procedure was concluded before puberty (~PND60-70).
