Table 1. Descriptive characteristics of participating genome-wide association studies in the Discovery and Replication analyses.
| A. Discovery sample | ||||||||||||
| Total | Ontario | CSHS/USC | Australasian | Mayo | Seattle | |||||||
| Case | Control | Case | Control | Case | Control | Case | Control | Case | Control | Case | Control | |
| Total sample, n (%) | 985 (35.8) | 1769 (64.2) | ||||||||||
| Female, n (%) | 718 (72.9) | 1295 (73.2) | ||||||||||
| Age, mean (SD) | 49.4 (10.8) | 51.6 (13.2) | ||||||||||
| Colon Cancer Family Registry | ||||||||||||
| Count, n | 602 | 991 | 164 | 497 | 71 | 0 | 101 | 188 | 129 | 0 | 137 | 306 |
| Female, n (%) | 335 (55.7) | 517 (52.2) | 96 (58.5) | 229 (46.1) | 45 (63.4) | 0 | 45 (44.5) | 97 (51.6) | 71 (55.0) | 0 | 78 (56.9) | 191 (62.4) |
| Age, mean (SD) | 53.2 (11.1) | 59.9 (10.9) | 56 (10.8) | 61.8 (10.1) | 54 (11.2) | 0 | 46 (7.4) | 48 (9.1) | 50 (9.5) | 0 | 57 (11.8) | 64 (7.5) |
| Breast Cancer Family Registry | ||||||||||||
| Count, n | 383 | 778 | 202 | 243 | 43 | 148 | 202 | 387 | - | - | - | - |
| Female, n (%) | 383 (100) | 778 (100) | 202 (100) | 243 (100) | 43 (100) | 148 (100) | 202 (100) | 387 (100) | - | - | - | - |
| Age, mean (SD) | 43.2 (6.5) | 41.0 (6.6) | 42 (6.1) | 39 (6.8) | 43 (8) | 40 (6.9) | 45 (6.2) | 42 (6) | - | - | - | - |
| A. Replication sample | ||||||||||||
| Total | WHI1 | WHI2 | VITAL | |||||||||
| Case | Control | Case | Control | Case | Control | Case | Control | |||||
| Total*, n | 293 | 2103 | 91 | 1174 | 187 | 805 | 15 | 124 | ||||
| Age, mean (SD) | 66.4 | 67.7 | 67.1 (7.1) | 69.3 (6.5) | 65.8 (6.3) | 65.5 (6.2) | 70 (4.8) | 67.2 (6.0) | ||||
*All subjects were female; CSHS: Cedars-Sinai Health System, formerly located at USC: the University of Southern California; WHI: Women’s Health Initiative, VITAL: VITamins And Lifestyle cohort